The Tennessee Titans (1-3) will host the Indianapolis Colts (2-3) at Nissan Stadium in Nashville, Tennessee on Sunday afternoon.
Opening the week, the Titans were listed as 1-point home underdogs but that spread has changed quite a bit since then with Tennessee now at -2.5 as of this writing.
Let’s take a look at who some of the experts and insiders around the league are taking in the Week 6 matchup:
| Expert | Pick | Score (if applicable) |
| Dan Graziano (ESPN) | Titans | N/A |
| Matt Bowen (ESPN) | Colts | N/A |
| Seth Wickersham (ESPN) | Titans | N/A |
| Pete Prisco (CBS) | Titans | 27-20 |
| John Breech (CBS) | Colts | 24-17 |
| Jordan Dajani (CBS) | Titans | 20-14 |
| Nate Davis (USA TODAY) | Titans | 24-20 |
| Lorenzo Reyes (USA TODAY) | Titans | 23-17 |
| Bill Bender (Sporting News) | Colts | 30-27 |
| Vinnie Iyer (Sporting News) | Colts | 20-17 |
It’s a bit of a mixed bag this week when it comes to picks. The above panel slightly favors the Titans and everyone sees it as a one-score game. Bill Bender of The Sporting News anticipates a high-scoring game at that.
Other experts and analysts from around the league lean more favorably towards the Colts with 67 percent predicting them to win, per NFL Pickwatch.
Fans are slightly more optimistic when it comes to the Titans with 38 percent predicting a Tennessee victory.